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GATE 2017-2018 :: GATE Biotechnology

  1. Under alkaline conditions, DNA is more stable than RNA because
  2. A.
    RNA forms secondary structures
    B.
    RNA is a single stranded molecule
    C.
    RNA has uracil in place of thymidine
    D.
    RNA is susceptible to hydrolysis

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  3. Which one of the following modifications is common toboth protein and DNA?
  4. A.
    SUMOylation
    B.
    Nitrosylation
    C.
    Methylation
    D.
    Ubiquitination

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  5. Protein A, which has strong affinity to Fc region of immunoglobulin, is extracted from
  6. A.
    Saccharomyces cerevisiae
    B.
    Staphylococcus aureus
    C.
    Streptococcus pyogenes
    D.
    Streptococcus sanguis

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  7. The first humanized monoclonal antibody approved for the treatment of breast canceris
  8. A.
    Rituximab
    B.
    Cetuximab
    C.
    Bevacizumab
    D.
    Herceptin

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  9. Which one of the following aminoacids in proteins does NOT undergo phosphorylation?
  10. A.
    Ser
    B.
    Thr
    C.
    Pro
    D.
    Tyr

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  11. The role of an adjuvant isto
  12. A.
    prolong the persistence of antigen
    B.
    cross link the antigen
    C.
    increase the size of antigen
    D.
    avoid inflammation

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  13. Endogenous antigens are presented on to the cell surface along with
  14. A.
    MHC-II
    B.
    MHC-I
    C.
    Fcγreceptor
    D.
    complement receptor

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  15. Human genome sequencing project involved the construction of genomic library in
  16. A.
    bacterial artificial chromosome
    B.
    pBR322
    C.
    bacteriophage
    D.
    pcDNA3.1

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  17. The nucleotide analogue used in DNA sequencing by chain termination method is
  18. A.
    1',3'-dideoxy nucleoside triphosphate
    B.
    2',3'-dideoxy nucleoside triphosphate
    C.
    2',4'-dideoxy nucleoside triphosphate
    D.
    2',5'-dideoxy nucleoside triphosphate

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  19. In nature, the horizontal gene transfer across bacteria is mediated by
  20. A.
    gene cloning followed by transformation
    B.
    conjugation and transformation
    C.
    conjugation only
    D.
    transformation only

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